Description: Statistics in Practice A new series of practical books outlining the use of statistical techniques in a wide range of application areas:

• Human and Biological Sciences
• Earth and Environmental Sciences
• Industry, Commerce and Finance

Cross-over Trials in Clinical Research Stephen Senn Biometrics, Medical Department, CIBA-Geigy Ltd, Basle, Switzerland Cross-over Trials in Clinical Research provides a practical introduction to this important tool within the pharmaceutical industry. Aimed at guiding practitioners in the methods of using cross-over designs efficiently, this book presents a fresh insight into how such trials may be designed and analysed. Key features of this comprehensive treatment are:

• A focus on the two-period AB/BA design, including the most up-to-date developments in this topic.
• Important aspects of special design— graphical and tabular presentation of trials, robust approaches to analysis, and practical issues in planning.
• Direct relevance to drug development with an approach rooted firmly in biology and pharmacokinetics rather than stressing the mathematical aspects.
• All techniques included are discussed and illustrated in detail with many practical examples drawn from the author’ s wide-ranging experience.

This book will prove an invaluable reference to all statisticians and researchers in the pharmaceutical industry. It will also appeal to physicians involved in clinical research.

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