Description: Preface. Editor biography. List of Contributors. I. History and Epidemiology of the Antiphospholipid Syndrome (R.A. Asherson). Milestones in the Antiphospholipid Syndrome (R.A. Asherson et al. ). Classification and Epidemiology of the Antiphospholipid Syndrome (M. Petri). II. Immunology and Pathophysiology of the Antiphospholipid Syndrome (Y. Shoenfeld). Lupus Anticoagulant: Detection, Standardization and Heterogeneity (D.A. Triplett, M.-C. Boffa). Antibodies to Cardiolipin and other Phospholipids (S.S. Pierangeli, E.N. Harris). &bgr;2-Glycoprotein I and anti-&bgr;2-Glycoprotein I Antibodies (P.G. De Groot et al. ). Anti-Prothrombin Antibodies (M. Galli). The Annexins: A Target of Antiphospholipid Antibodies (J.H. Rand, Xiao-Xuan Wu). Antiphospholipid/Endothelial Cell Interaction in the Pathogenesis of the Antiphospholipid Syndrome (P.L. Luigi et al. ). Tissue Factor, Protein C pathway and other Hemostasis Abnormalities in the Pathogenesis of the Antiphospholipid Syndrome (R.A.S. Roubey). Systemic Involvement in the Antiphospholipid Syndrome: Lessons from Animal Models (Y. Shoenfeld et al. ). Cytokines, Th1/Th2 and Adhesion Molecules in the Antiphospholipid Syndrome (M. Ehrenfeld et al. ). Lessons from Monoclonal Antiphospholipid Antibodies (M. Abu-Shakra, Y. Shoenfeld). Immunogenetics of the Antiphospholipid Syndrome (G.D. Sebastiani et al. ). Pathology of the Antiphospholipid Syndrome (E. Reyes, D. Alarcn-Segovia). Antiphospholipid Antibodies in Human and Murine Atherogenesis (Y. Sherer, Y. Shoenfeld). III. Clinical Features in the Antiphospholipid Syndrome (R. Cervera). Thrombotic Manifestations in the Antiphospholipid Syndrome (J.O. Ros et al. ). Neurologic Manifestations in the Antiphospholipid Syndrome (R.L. Brey et al. ). Cardiac and Pulmonary Manifestations in the Antiphospholipid Syndrome (G. Espinosa et al. ). Renal, Hepatic and other Intra-abdominal Manifestations in the Antiphospholipid Syndrome (P. von Landenberg et al. ). Fetal and Obstetric Manifestations and Infertility in the Antiphospholipid Syndrome (F. Carmona, J. Balasch). Osteo articular Manifestations in the Antiphospholipid Syndrome (F. Liot, O. Meyer). Ophthalmic and Otological Manifestations in the Antiphospholipid Syndrome (A. Montehermoso et al. ). Dermatologic Manifestations in the Antiphospholipid Syndrome (C. Frances, J.C. Piette). Endocrine Manifestations in the Antiphospholipid Syndrome (R.A. Asherson, M. Petri). Hematological Abnormalities in the Antiphospholipid Syndrome (G. Espinosa et al. ). Immunological Abnormalities in the Antiphospholipid Syndrome (A. Tincani et al. ). ''Primary'', ''Secondary'', ''Seronegative'', ''Catastrophic'' and other Subsets of the Antiphospholipid Syndrome (R.A. Asherson et al. ). Pediatric and Familial Antiphospholipid Syndrome (L.R. Sammaritano, J.-C. Piette). Antiphospholipid Antibodies and Malignancies (R.A. Asherson et al. ). Antiphospholipid Antibodies and Vasculitis (R.A. Asherson, R.A. Levy). Antiphospholipid Antibodies and Infections-Drugs (G. Zandman-Goddard et al. ). IV. Management and Prognosis of the Antiphospholipid Syndrome (J.-C. Piette). Management of Thrombosis in the Antiphospholipid Syndrome (R.H.W.M. Derksen et al. ). Management of Reproductive Failure in the Antiphospholipid Syndrome (J. Balasch et al. ). Management of the Difficult Aspects of the Antiphospholipid Syndrome (D. Erkan et al. ). Course and Prognosis of the Antiphospholipid Syndrome (C. Drenkard, D. Alarcn-Segovia). Novel Perspectives in the Treatment of the Antiphospholipid Syndrome - from Anticoagulation to Immunomodulation (M. Blank et al. ). V. Appendix. The Antiphospholipid Syndrome in the Internet (M. Ramos-Casals, R. Cervera). A Patients Guide to the Antiphospholipid Syndrome (J. Berman et al. ). Subject Index.

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